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Neuroscience Research Priority Area

2016 KNI Clinical-Translation Research Symposium Abstracts

Acute Injury

Pioglitazone Improves Functional Neuroprotection Following Spinal Cord Injury

Neuroprotective Effects of Inhibition of α5β1  Integrin Following Experimental Stroke: A Dual Centre Pre-Clinical Study

Leukemia Inhibitory Factor Confers Neuroprotection During Ischemic Stroke Through Enhanced LIFR Expression and Membrane Localization

Peripheral Macrophages are Viable Therapeutic Targets in Traumatic Brain Injury

Chronic Neurodegeneration

PERK Inhibition in rTg4510 Mouse Model of Tauopathy Rescues Impairment Through elF2α-independent pathway

Translating CD33 Genetics to an Alzheimer's Disease Pharmacologic Agent

Therapeutic Development of a Novel siRNA Compound Targeting Alpha-Synuclein

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Multiple Ascending Dose Study of AT-001 Yeast Selenium for the Prevention of Alzheimer's

Vascular Impairment

Diabetes and the Brain: A Hidden Trigger of Brain White Matter Disease

Vascular Dementia and Angiotensin Signaling

Observing Changes in Cerebral Blood Flow and Hippocampal Metabolites by Magnetic Resonance After a Closed Head Traumatic Brain Injury in Mice

Factors Associated with Moyamoya Syndrome in the Kentucky Regional Population

Pain and Headache

Molecular and Electrophyisological Characterization of Neuropeptide Y Y1 Receptor-expressing Neurons in the Substantia Gelatinosa of the Spinal Cord

Is Chronic Pain an Initiator of Tauopathy?

Outcomes Following the Conservative Management of Patients with Non-radicular Peripheral Neuropathic Pain

Visual Field Deficits in Patients with Headache Disorders: A 2-year Prospective Cohort Study

Traumatic Brain Injury Poster

Insulin-like Growth Factor-1 Overexpression Mediates Regional Alterations to the mTOR Signaling Pathway in the Hippocampus Following TBI

mTOR Inhibition After Controlled Cortical Impact Alters Hilar Interneuron Excitability

Synaptic Mitochondria Sustain More Damage than Non-Synaptic Mitochondria Following Traumatic Brain Injury and are Protected by Cyclosporine A 

Brain Injury Signaling Events After Expression of Mitochondria Associated microRNA

Phenelzine Administration following Traumatic Brain Injury Improves Mitochondrial FUnction and Reduces Lipid Peroxidation and Cytoskeletal Degradation

Effects of Controlled Cortical Impact Brain Injury on Cell Loss and Neurogenesis in the Mouse Dentate Gyrus

Activation of PERK in Controlled Cortical Impact Model of Traumatic Brain Injury

IL-1β Levels After TBI can be Inhibited with the Therapeutic MW151 without Affecting Microglial Physiological Responses

Stroke and Vasculopathy Poster

Elucidating Subtypes and Risk Factors of Brain Arteriosclerosis

Intra-arterial IL-1α is Well Tolerated and Neuroprotective After Experimental Ischemic Stroke

Amylin Vasculopathy, a Novel Mechanism of Cerebrovascular Injury and Neurologic Deficits in Diabetes

Early Non-white Matter Changes in Cerebrovascular Integrity in Mouse Brain Following Bilateral Carotid Artery Stenosis

Gait Abnormalities, Impaired Balance and Brain White Matter Hyperintensities in a Rat Model of Late-Onset Type-2 Diabetes

Intra-arterial Pharmacotherapy Administration Following Experimental Stroke Improves Neuronal Survival and Functional Outcome

Spinal Cord Injury Poster

Non-invasive Brain Stimulation Paired with Robot-assisted Gait Training After Spinal Cord Injury

Chronic Rapamycin Administration After High-Thoracic Spinal Cord Injury Exacerbates Cardiovascular Dysfunction

Age Increases Reactive Oxygen Species Production in Macrophages and Potentiates Oxidative Damage After Spinal Cord Injury

Compression Decreases Anatomical and Functional Recovery and Alters Inflammation after Contusive Spinal Cord Injury

Mitochondrial Transplantation into the Injured Spinal Cord Improves Cellular Respiration

Flubendazole Improves Recovery Following Spinal Cord Injury in Rats

Epilepsy Poster

Optogenetic-induced Glutamate Release in the Rodent Hippocampus and Frontal

Sudden Unexpected Death in Epilepsy and Functional Remodeling of Vagal Complex Activity in a Mouse Model of Temporal Lobe Epilepsy

Lafora Epilepsy - Basic Mechanisms to Therapy

Precision Imaging and Histological Phenotyping for RNA Profiling of Human Epilepsy Tissue

Sleep Poster

Tunable Somatosensory Stimulation for Selective Sleep Restriction Studies in Rodents

Effect of Temperature on Sleep Regulation in an Animal Epilepsy Model

A Mathematical Model of Ultradian Sleep-Wake Regulation in Rodents

Effect of Vigilance State on the Spatial Profile of Cortical High Frequency Oscillations

Autonomic Variables and their Correlation with Electrophysiological Markers in Epilepsy Patients Undergoing Phase II Presurgical Evaluation

Memory/Aging Poster

Correlating Common TDP-43 and Tau Pathologic Patterns in the Aged Human Hippocampus

Manganese-Enhanced Magnetic Resonance Imaging (MEMRI)-Based Identification of Neuronal Dysfunction Before the Appearance Tau Pathology in rTg4510 Mice

Aβ Imaging Ligand Pittsburgh Compound B Binding in AD Frontal Cortical Synaptosomes is in Glutamatergic Synapses

Declines in Default-mode Network Structure and Function Mediate the Negative Effects of Alzheimer's Pathology on Executive Function in Older Adults 

Clinical Impact of MRI-Evident, Deep vs Periventricular T2 Abnormalities on Cognitive Impairment in Cerebrovascular Disease and Other Leukopathologies

A Multiple Ascending Dose Study of HDAC Inhibition for Modulation of Apoj/Clusterin Risk in Alzheimer's Disease

Acute Insulin Treatment of Hippocampal Neurons Highlights New Mechanisms of Action

Indentification of Novel Tau Interactions with Endoplasmic Reticulum Proteins in Alzheimer's Disease Brains

Aged Animals Appear Cognitively and Behaviorally Hyporesponsive to Chronic Restraint (Psychosocial Stress) Compared to Young Animals

Selective Modulation of Neuroinflammation by Targeting p38α MAPK with a Novel, Isoform-specific Inhibitor, MW150, in an Alzheimer's Disease Mouse Mode

The Role of Autophagy and the UPR in the Development of Alzheimer Disease in a Mouse Model of Down Syndrome Neuropathology

The Anti-NPI: A Novel Tool for Assessment of Neuropsychiatric Symptoms in Clinical Trials for Prodromal Alzheimer's Disease

Movement Disorders Poster

Using a Modified Cannula Delivery System to Implant Sural Nerve Grafts into the Rhesus Macaque Midbrain

Pathological Findings from Two Parkinson Disease Patients After Intraputaminal GDNF Infusion

Non-invasive Delivery of an Amidated Neuroactive Peptide in Models of Parkinson's Disease

Distinct Synuclein Seeds in Parkinson Disease and Multiple System Atrophy

Combining Cell Therapy with Deep Brain Stimulation for the Treatment of Parkinson's Disease

Deep Brain Stimulator Implantation Under General Anesthesia

Inflammatory Mechanism Poster

Intraneuronal Amylin Disposition, Peroxidative Membrane Injury and Increased IL-1β Synthesis in Brains of AD Patients with T2D and Diabetic HIP Rats

Microglia Heterogeneity in the Hippocampus of Alzheimer's Disease, Dementia with Lewy bodies, and Hippocampal Sclerosis of Aging

Addressing Innovation in CNS Drug Discovery: Functional or Single Molecular Target Approaches to Novel Compounds that Attenuate Synaptic Dysfunction

TREM-2 Induced Microglial Activation Promotes the Clearance of Amyloid-beta in an AD Mouse Model

Cognition and Affect in Possible Serial Autoimmune Episodes of Anti-NMDA-Receptor Encephalitis

Targeting Neuroinflammation in Vascular Cognitive Impairment with a Novel, CNS-Penetrant, Small Molecule Experimental Therapeutic

Therapeutic Approaches to Target Inflammation Following TBI Through Inhibition of the p38α MAPK

Addiction Poster

Novel Synthetic Isoflavanoid for the Treatment of Alcohol and Nicotine Co-use

Discovery of Vesicular Monoamine Transporter-2 Inhibitors as Potential Treatment for Methamphetamine Abuse: N-Butyl(1-methyl-2-phenylethyl)amine isome

Identifying Organelle Specific Intracellular Changes in Nicotinic Acetylcholine Receptors in Response to Ligand Exposure Using Fluorescence Microscopy

JPC-077 Interacts with VMAT2 to Decrease the Neurochemical and Behavioral Effects of Methamphetamine

Directed Evolution of Terpene Synthases to Alter Product Specificity Towards Compounds with Anxiolytic Properties

Plasticity/Pathology Poster

RIT1 is Required for IGF1-mediated Neurogenesis

An Examination of Corticomotor Plasticity in Individuals with and without Chronic Ankle Instability

Diabetes-induced Changes in Brainstem GCK Expression

Signaling and Expression of a Truncated, Constitutively Active Human Insulin Register

DREADD(ed) Evidence for Modulation of Blood (glucose) by the Dorsal Hindbrain

Recovery/Rehab Poster

Early Tracheostomy and Percutaneous Endoscopic Gastrostomy in Hemorrhagic Stroke Patients: Associated Factors and Effects on Hospitalization

Nerve Stimulation Paired with Task-Oriented Training Improves Chronic, Severe Hemiparesis After Stroke: A Randomized Trial

Closed Loop Afferent Electrical Stimulation for Recovery of Hand Function in Individuals with Motor Incomplete Spinal Injury: Early Clinical Results

Kentucky Care Coordination for Community Transitions (KC3T)

An Electromyography Study of Muscular Endurance during the Posterior Shoulder Endurance Test

Physician and Physical Therapist Communication is Associated with Earlier Mobility and Decreased Length of Stay in the Neuroscience Population

Optimizing Transcranial Direct Current Stimulation for Motor Recovery from Sever Post-stroke Hemiparesis

Headache Pain Poster

Fingolimod Ameliorates Central Neuropathic Pain

The Spinal Effects of the VGF-derived Peptide TLQP-21 are Mediated by the Complement 3a Receptor

Latent Sensitization is Masked by Spinal Mu and Kappa, but not Delta Opioid Receptor Analgesia in a Preclinical Model of Postoperative Pain

15-Deoxy-Delta-12,14-prostaglandin J2 Activates Peripheral Peroxisome Proliferator-activated Receptor Gamma Gamma and Opioids Receptors to Reduce Inflammatory Muscle Pain

Sex Differences in the Therapeutic Effects of Pioglitazone on Type II Painful Diabetic Neuropathy 

Cannabinoid Receptor 2 Agonist Attenuates Pain Related Behavior in Rats with Chronic Alcohol/High Fat Diet Induced Pancreatitis

Other Conditions Poster

Research Plan for a Case Report of D-Lyxo-Hexulose Treatment in an Infant with Prader-Willi Syndrome

Utility of the CAARS Validity Scales in Idnetifying Feigned ADHD, Random Responding, and Genuine ADHD

A Prospective Evaluation of Swallowing and Speech in Patients with Neurofibromatosis Type 2

Acetyl-L-carnitine Attentuates Hypersensitivity in an Alcohol/high-fat Diet Induced Rat Chronic Pancreatitis Model

Dual PI3K/Akt Inhibition: A New Strategy to Improve Drug Delivery in Glioblastoma Therapy

Cardiorespiratory Fitness is Associated with Executive Function in Older Adults

Neuroscience Research Priority Area

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