The Scientist
Danielle Gerhard, PhD
In 2015, Jennifer Byrne, a cancer researcher at the University of Sydney, noticed something strange while browsing papers related to her past research. A handful of papers recently published by separate research groups had all linked the expression of a gene that she had cloned in the 1990s with different types of cancer. Byrne, who had studied cancer-associated genes for more than two decades, recalled, “That struck me as strange because for many years no one had been interested in this gene.” In fact, in Byrne and her colleagues’ investigation of the gene, they realized early on that there was limited evidence for this gene as an important driver of cancer development. “If we, as the people who cloned the gene, weren't interested in the gene in cancer, well, why would anyone else be?” she wondered.
When she looked into the details of the papers, including the methods and materials sections, she noticed several mistakes in the nucleotide sequences.1 “[The nucleotide sequences] weren't peripheral to the research; they were absolutely core to the research, so if they were wrong, everything was wrong,” said Byrne.